Further Information About Oestrogen
(Applicable Regardless of Administration Method)

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Keep the medication in a sealed container
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Store it at room temperature
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Keep it away from moisture
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Avoid exposing it to heat
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Keep out of direct sunlight

Medications That May Reduce the Effectiveness of Oestrogen
(In alphabetical order)
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Aprepitant
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Bosentan
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Carbamazepine
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Efavirenz
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Eslicarbazepine
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Fosaprepitant
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Fosphenytoin
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Modafinil
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Nevirapine
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Oxcarbazepine
All of the above medications have been deemed to, potentially, moderately effect the efficacy of oestrogen, based on theoretical evidence.¹
Citations: ¹ https://bnf.nice.org.uk/interactions/estradiol/
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Perampanel
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Phenobarbital
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Phenytoin
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Primidone
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Rifabutin
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Rifampicin
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Ritonavir
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Rufinamide
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St John's Wort
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Topiramate

Other medications that may interact with Oestrogen
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Lamotrigine
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Talk to your doctor before using Lamotrigine together with oestrogen. Combining these medications may reduce the blood levels and effects of Lamotrigine. You may need a dose adjustment if you have been taking Lamotrigine and are starting treatment with oestrogen. Similarly, if oestrogen is discontinued, your dosage of Lamotrigine may need to be readjusted. Contact your doctor if your condition changes or you experience loss of seizure control during treatment with these medications.
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Levothyroxine
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Before taking oestrogen, tell your doctor if you also use levothyroxine. You may need dose adjustments or special tests in order to safely take both medications together. If you are already taking oestrogen and levothyroxine, your thyroid levels may need to be measured if your dose of oestrogen is changed or stopped. You should notify your doctor if you have symptoms of low thyroid such as tiredness, feeling cold, constipation, unexplained weight gain, depression, joint or muscle pain, thinning hair or hair loss, dry skin, hoarseness, and abnormal menstrual periods¹
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